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專任教師
林伯雄   教授兼系主任
Lin, Po-Hsiung
美國北卡大學教堂山分校博士
+886-4-22840441 ext 511
環境毒理暨醫學實驗室
經歷
民國52年生
75年東海大學環境科學系學士
77至79年台灣大學環境工程學研究所研究助理
81年美國加州大學柏克萊分校生醫及環境衛生科學系碩士
81年美國加州大學柏克萊分校公共衛生學院研究助理
85年美國北卡大學教堂山分校環境科學及工程系博士
86至88年美國北卡大學教堂山分校醫學院毒理組博士後研究員
88年至94年 助理教授
94年至99年 副教授
99年至今 教授
研究領域
生物性偵測指標之核酸及蛋白質胼合物方法發展及應用
環境及工廠作業場所有機污染物之活性代謝物曝露劑量評估
化學致癌物之致癌機轉及致基因性毒害作用研究
雌性激素及環境荷爾蒙效應研究
乳癌預防醫學之生物指標之研究
環境污染物分析及自動監測

Development and application of DNA and protein adducts as biomarkers of exposure
Characterization of metabolic activation and tissue dosimetry of organic pollutants
Investigation of carcinogenic and genotoxic effects of chemical carcinogens
Analysis of estrogenicity of endocrine disruptors
Biomarkers of breast cancer risk.
Environmental pollutant analysis and automatic monitoring
授課課程
部別
年級
課程名稱(中英文)
學期
學分數
授課語言
研究所 碩士班
碩士班
課程名稱：環境與職業醫學導論 Introduction to Environmental and Occupational Medicine (Elective Subjects)
學期：下學期
學分數：3
授課語言：英文
大學部 三年級
三年級
課程名稱：環境毒物學概論Introduction to Environmental Toxicology (Elective Subjects)
學期：下學期
學分數：2
授課語言：英文
大學部 一年級
一年級
課程名稱：環境科學概論Introduction to Environmental Science (Required Course)
學期：上學期
學分數：3
授課語言：英文
研究所 碩士班
碩士班
課程名稱：環境毒理學Environmental Toxicology (Elective Subjects)
學期：上學期
學分數：3
授課語言：英文
研究所 碩士班
碩士班
課程名稱：環工生物原理Biological Principle in Environmental Engineering (Required Course)
學期：上學期
學分數：3
授課語言：英文
學術著作
A.期刊
1.
Che Lin, Ding-Ru Chen, Sheng-Yen Hsu, Chi-Yen Feng, Shou-Jen Kuo, Dar-Ren Chen, Wei-Chung Hsieh, Po-Hsiung Lin, “Profiling of Protein Adducts of Estrogens Quinones in 5-year Survivors of Breast Cancer without Recurrence,” Cancer Control, 02 2022. (SCI)
2.
Dar-Ren Chen, Wei-Chung Hsieh, Yi-Lun Liao, Kuo-JueiLin, Yu-Fen Wang, Po-HsiungLin, “Imbalances in the disposition of estrogen and naphthalene in breast cancer patients: a potential biomarker of breast cancer risk,” Scientific Reports, vol.10, no.1, 07 2020. (SCI)
3.
Chiung-Ta Wu, Chen-Yu Chang, Yi-Ying Li, Yu-Lun Kuan, Po-Hsiung Lin, “An efficiency analysis for the production of chlorine dioxide by the electrolysis of brine in seawater desalination plants,” Water Quality Research Journal, vol.54.2, no.127-133, 05 2019. (SCI)
4.
Po-Hsiung Lin, Hui-Ju Yang, Wei-Chung Hsieh, Che Lin, Ya-Chi Chan, Yu-Fen Wang, Yuan-Ting Yang, Kuo-Juei Lin, Li-Sheng Lin, Dar-Ren Chen, “Albumin and hemoglobin adducts of estrogen quinone as biomarkers for early detection of breast cancer,” PLOS ONE, 09 2018. (SCI)
5.
Chiung-Ta Wu, Chen-Yu Chang, Yi-Ying Li , Po-Hsiung Lin, “Feasibility study for the production of multi-oxidants from the desalination of seawater brine,” Journal of Water and Climate Change, 09 2018. (SCI)
6.
Junyan Yan, Liliang Chen, Chih-Ching Huang, Shih-Chun Candice Lung, Lingyan Yang, Wen-Cheng Wang, Po-Hsiung Lin, Guangli Suo, Chia-Hua Lin, “Consecutive evaluation of graphene oxide and reduced graphene oxide nanoplatelets immunotoxicity on monocytes,” Colloids and Surfaces B: Biointerfaces, vol.153, pp.300-309, 05 2017. (SCI)
7.
Wei-Chung Hsieh, Che Lin, Dar-Ren Chen, Wen-Fa Yu, Guan-Jie Chen, Suh-Woan Hu, Chin-Chen Liu, Mao-Huei Ge, Chang-Sin Ruan, Cheng-You Chen, Chia-Hua Lin, Po-Hsiung Lin, “Genetic polymorphisms in APE1 Asp148Glu(rs3136820) as a modifier of the background levels of abasic sites in human leukocytes derived from breast cancer patients and controls,” Breast Cancer, vol.24, pp.420-426, 05 2017. (SCI)
8.
Shou-Tung Chen, Dar-Ren Chen, Ju-Pin Fang, Po-Hsiung Lin, “2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast cancer cells through alteration of CYP1A1 and CYP1B1 expression,” Breast Cancer, vol.22, no.3, pp.269-279, 05 2015. (SCI)
9.
Che Lin,Dar-Ren Chen, Shu-Li Wang, Wei-Chung Hsieh, Wen-Fa Yu, Tzu-Wen Wang, Chen-His Tsai, Hz-Han Wei, Ben-Jei Tsuang, Po-Hsiung Lin* , “Cumulative Body Burdens of Polycyclic Aromatic Hydrocarbons Associate with Estrogen Bioactivation in Pregnant Women: Protein Adducts as Biomarkers of Exposure ,” Journal of Environmental Science and Health, Part A, vol.49, pp.634-640, 01 2014. (SCI)
10.
CheLin, Wei-Chung Hsieh, Dar-RenChen,Shou-Jen Kuo, Wen-FaYu, Suh-WoanHu, Hung-Jie Sue, Mao-HuiKo, Chang-HsinJuan, Kuo-SuanChung, Po-Hsiung Lin*, “Hemoglobin adducts as biomarkers of estrogen homeostasis: elevation of estrogenquinones as a risk factor for developing breast cancer in Taiwanese Women,” Toxicology Letters, vol.225, pp.386-391, 01 2014. (SCI)
11.
Shou-Tung Chen, Dar-Ren Chen, Chia-Chi Lin, Yi-Shiau Liu, Che Lin, Pei-Tzu Hung, Chia-Wen Jao, Po-Hsiung Lin*, “Airborne particulate collected from central Taiwan induces DNA strand breaks, Poly(ADP-ribose) polymerase-1 activation, and estrogen-disrupting activity in human breast carcinoma cell lines ,” Journal of Environmental Science and Health, Part A, vol.48, pp.173-181, 01 2013. (SCI)
12.
Che Lin, Dar-Ren Chen, Wei-Chung Hsieh, Wen-Fa Yu, Ching-Chiuan Lin, Mao-Huei Ko, Chang-Hsin Juan, Ben-Jei Tsuang, Po-Hsiung Lin*, “Investigation of the cumulative body burden of estrogen-3,4-quinone in breast cancer patients and controls using albumin adducts as biomarkers,” Toxicology Letters , vol.218, pp.194-199, 04 2013. (SCI)
13.
Chen ST, Chen DR, Fang JP, Lin PH., “2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast cancer cells through alteration of CYP1A1 and CYP1B1 expression.,” Breast Cancer, vol.21, 05 2013. (SCI)
14.
Dar-Ren Chen, Shou-Tung Chen, Tzu-Wen Wang, Chen-His Tsai, Hz-Han Wei,Guan-Jie Chen, Tsung-Chou Yang, Che Lin, Po-Hsiung Lin* , “Characterization of estrogen quinone-derived protein adducts and their ,” Toxicology Letters , vol.202, pp.244-252, 02 2011. (SCI)
15.
Lin, C.H., Huang, C.L., Chuang, M.C., Wang, Y.J., Chen, D.R., Chen, S.T., Lin, P.H.*, “Protective role of estrogen receptor-alpha on lower chlorinated PCB congener-induced DNA damage and repair in human tumoral breast cells,” Toxicol Lett, vol.188, no.1, pp.11-19, 01 2009. (SCI)
16.
Lin PH, Chen DR, Wang TW, Lin CH, Chuang MC., “Investigation of the cumulative tissue doses of naphthoquinones in human serum using protein adducts as biomarker of exposure.,” Chemico-biological Interactions, vol.181, no.1, pp.107-114, 06 2009. (SCI)
17.
Lin, P.H.*, Lin, C.H., Huang, C.C., Fang, J.P., Chuang, M.C., “2,3,7,8-Tetrachlorodibenzo-p-Dioxin Modulates the Induction of DNA Strand Breaks and Poly(ADP-ribose) polymerase-1 Activation by 17b-Estradiol in Human Breast Carcinoma Cells Through Alteration of CYP1A1 and CYP1B1 Expression,” Chem. Res. Toxicol, vol.21, pp.1337-1347, 01 2008. (SCI)
18.
Lin, P.H.*, Lin, C.H., Huang, C.C., Chuang, M.C., Lin, P., “2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines.,” Toxicology Letters, vol.172, pp.146-158, 01 2007. (SCI)
19.
Lin, C.H. and Lin, P.H.* , “Induction of ROS formation, poly(ADP-ribose)polymerase-1 activation and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells.,” Chemico-Bilolgical Interactions, vol.162, pp. 181-194., 01 2006. (SCI)
20.
Lin, C.H., Huang, C.C., Wang, T.W., Wang, Y.J., Lin, P.H.*, “Disparity in the Induction of Glutathione Depletion, ROS Formation, Poly(ADP-Ribose)Polymerase-1 Activation, and Apoptosis by Quinonoid Derivatives of Naphthalene in Human Cultured Cells.,” Chemico-Biological Interactions, vol.165, pp.200-210, 01 2006. (SCI)
21.
Lin, P.H.*, Pan, W.C., Kang, Y.W., Chen, Y.L., Lin, C.H., Lee, M.C., Chou, Y.H. and Nakamura, J., “Effects of Naphthalene Quinonoids on the Induction of Oxidative DNA Damage and Cytotoxicity in Calf Thymus DNA and in Human Cultured Cells.,” Chem. Res. Toxicol.,, vol.18, pp.1262-1270., 01 2005. (SCI)
22.
Lin, C.H., Leow, H.T., Huang, S.C., Nakamura, J., Swenberg, J.A., and Lin, P.H*, “Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells.,” Chem. Res. Toxicol, vol.18, pp. 257-264., 01 2005. (SCI)
23.
Lin, P.H., Kuo, Y.L, Lee, C.M, Shi H.P, Wang, S.H, Wu, S.H, Pan, W.C, Cheng, C.C., Lin, C.H.,, “Microbial degradation modulates the (anti) estrogenicity of environmental estrogens.,” journal of Engineering National Chung Hsing University, vol.15, pp.181-196, 01 2004. (SCI)
24.
Lin, P.H., Sangaiah, R., Ranasinghe, A., Ball, L.M., Swenberg, J.A., and Gold, A., “Synthesis of chlorinated and non-chlorinated biphenyl-2, 3-and 3,4-catechols and their [2H3]-isotopomers,” Organic and Biomolecular Chemistry. formerly Journal of the Royal Chemical Society, Perkin Transactions,, vol.2, pp.001-006, 01 2004. (SCI)
25.
Tsai, C.H., Lin, P.H. and Rappaport, S.M., ““Formation and removal of pentachlorophenol-drived protein adducts in rodent liver under acute, subchronic, and chronic dosing regimens.”,” Toxicological Sciences, vol.73, pp.26-35, 01 2003. (SCI)
26.
Lin, P.H., Nakamura, J., Yamaghuji, Y., Asakura, S., and Swenberg, J.A.,, “”Aldehydic DNA lesions induced by catechol estrogen in calf thymu DNA.”,” Carcinogenesis, vol.24, pp. 1133-1141, 01 2003. (SCI)
27.
Lin, P.H., Leow, H.T., and Hou, K.L.,, ““Parallel induction of apurinic/apyrimidinic sites and DNA strand breaks in calf thymus DNA by 4-chlorocatechol.”,” Journal of Engineering National Chung Hsing University, vol.13, pp.201-209, 01 2002. (SCI)
28.
Tsai, C.H., Lin, P.H., Waidyanatha, S., and Rappaport, S.M., ““Fractionation of protein adducts in rats and mice dosed with [14C] pentachlorophenol.”,” Archives of Toxicology, vol.76, pp. 628-633, 01 2002. (SCI)
29.
Lin, P.H., La, D.K., Nakamura, J., and Swenberg, J.A., ““Analysis of DNA adducts in rats exposed to pentachlorophenol.”,” Carcinogenesis, vol.23, pp.365-369, 01 2002. (SCI)
30.
Lin, P.H., Nakamura, J., Yamaguchi, S., La, D.K., Upton, P.B., and Swenberg,J.A., ““Induction of direct adducts, 5’-cleaved apurinic/apyrimidinic sites, and oxidized bases in nuclear DNA of human HeLa S3 tumor cells by tetrachlorohydroquinone.”,” Carcinogenesis, vol.22, no.4, pp.635-639, 01 2001. (SCI)
31.
Lin, P.H., Nakamura,J., Yamaguchi, S., La, D.K., and Swenberg, J.A., ““Oxidative damage and direct adducts in calf thymas DNA induced by tetrachlorohydroquinone and tetrachloro-1,4-benzoquinone.” ,” Carcinogenesis, vol.22, no.4, pp.627-634, 01 2001. (SCI)
32.
Tsai, C.H., Lin, P.H., Waidyanatha, S., and Rappaport, S.M.,, ““Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver.” ,” Chemico-Biological Interactions,, vol.134, pp.55-71, 01 2001. (SCI)
33.
Lin, P.H., Sangaiah, R., Ranasinghe, A., Upton, P.B., La, D.K., Gold, A., and Swenberg, J. A.,, ““Formation of quinonoid-derived protein adducts in the liver and brain of sprague-dawley rats administered 2,2’,5,5’-tetrachlorobiphenyl.”,” Chemical Research In Toxicology, vol.13, pp. 710-718, 01 2000. (SCI)
34.
Lin, P.H., Waidyanatha, S., Pollack, G.M., Swenberg, J.A., and Rappaport, S.M.,, ““Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol.”,” Toxicological Sciences, vol.47, pp.126-133, 01 1999. (SCI)
35.
Lin, P.H., Waidyanatha, S., Pollack, G.M., and Rappaport, S.M.,, ““Dosimetry of chlorinated quinone metabolites of pentachlorophenol in the livers of rats and mice based upon measurement of protein adducts.”,” Toxicology And Applied Pharmacology, vol.145, pp. 399-408, 01 1997. (SCI)
36.
Lin, P.H., Waidyanatha, S., and Rappaport, S.M., “Dosimetry of chlorinated quinone metabolites of pentachlorophenol in the livers of rats and mice based upon measurement of protein adducts.,” TOXICOLOGY AND APPLIED PHARMACOLOGY, vol.145, pp.399–408, 01 1996. (SCI)
37.
Waidyanatha, S., Lin, P.H., and Rappaport, S.M.,, ““Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats.”,” Chemical Research In Toxicology, vol.9, pp. 647-653, 01 1996. (SCI)
38.
Waidyanatha, S., McDonald, T. A., Lin, P.H., and Rappaport, S.M., ““Measurement of hemoglobin and albumin adducts of tetrachloro-1,4-benzoquinone.” ,” Chemical Research In Toxicology, vol.7, pp.463-468, 01 1994. (SCI)
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